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KMID : 0370219970410020195
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Yakhak Hoeji
1997 Volume.41 No. 2 p.195 ~ p.202
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Clinical Pharmacokinetics of Vancomycin in Gastric Cancer Patients
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최준식/Choi JS
장일효/범진필/Chang IH/Burm JP
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Abstract
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The purpose of this study was to determine pharmacokinetic parameters of vancomycin using two point calculation(TPC) and Bayesian methods in 16 Korean normal volunteers and 15 gastric cancer patients. Nonparametric expected maximum(NPEM) algorithm for calculation of population pharmacokinetic parameter was used, and these parameters were applied for clinical pharmacokinetic parameters by Bayesian analysis. Vancomycin was administered 1.0g every 12 hrs for 3 days by IV infusion over 60 minutes. The volume of distribution(Vd), elimination rate constant(Kel) and total body clearance(CLt) of vancomycin in normal volunteers using TPC method were 0.34 +/- 0.06 L/kg, 0.19 +/- 0.01 hr-1 and 4.08 +/- 0.93 L/hr, respectively, The Vd, Kel and CLt of vancomycin in gastric cancer patients using TPC method were 0.46 +/- 0.06 L/kg, 0.17 +/- 0.02 hr-1 and 4.84 +/- 0.57 L/hr respectively. There were significant differences(p2)-1, 0.631 +/- 0.0036 L/kg in gastric cancer patients using NPEM algorithm respectively. The Vd and Kel were 0.63 +/- 0.005 L/kg, 0.15 +/- 0.027 hr-1 for gastric cancer patients using Bayesian method. There were significant differences(p<0.05) in vancomycin pharmacokinetics between Bayesian and TPC methods. It is considered that the population parameter in the patient population is necessary for effective Bayesian method in clinical pharmacy practise.
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